Consult a health care practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression, and/or hypertension . Consult a health care practitioner prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity . These may include but are not limited to L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over-the-counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. If symptoms worsen or persist for more than 3 weeks (chronic insomnia), consult a health care practitioner. Some people may experience diarrhea, nausea, vomiting, and/or abdominal pain . Discontinue use if you show signs of weakness, oral ulcers, skin changes, or abdominal pain accompanied by severe muscle pain. Do not use if you are taking blood pressure, immunosuppressive or sedative/hypnotic medication or if you are pregnant or breastfeeding or have scleroderma. Keep out of reach of children.